ISSN 0021-3454 (print version)
ISSN 2500-0381 (online version)
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vol 67 / February, 2024
Article

DOI 10.17586/0021-3454-2022-65-5-343-349

UDC 681.785.24

APPLICATION OF THE TOTAL INTERNAL REFLECTION METHOD FOR THE STUDY OF LIQUID-PHASE MEDIUM BASED ON BOTULINUM TOXIN

O. V. Gromov
University under the Inter-Parliamentary Assembly of EurAsEC, Department of Vehicle Service;


R. B. Guliyev
University at the EurAsEC Inter-Parliamentary Assembly, Department of Mathematics and Information Technologies;


T. A. Chernyak
St. Petersburg State University of Civil Aviation, Department of Higher Mathematics; Head of the Department


E. E. Majorov
Saint-Petersburg state university of aerospace instrumentation; Associate professor


A. V. Dagaev
St. Petersburg University of Management Technologies and Economics, Department of Information Technologies and Mathematics; Associate Professor


I. S. Tayurskaya
University at the EurAsEC Inter-Parliamentary Assembly, De-partment of Mathematics and Information Technologies;


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Abstract. Application of the total internal reflection method for the study of liquid-phase media based on botulinum toxin is considered. A comparative analysis of these drugs is carried out. Structural and functional scheme, as well as technical and operational characteristics of the developed refractometric system are presented. Botulinum toxin-based drugs - Botox, Xeomin, and Dysport - are used as objects of research. Experimental results of measurements of the concentration dependences of the refractive index in these preparations are obtained. It is shown that temperature dependences for Botox, Xeomin, and Dysport at various concentrations make it possible to change the algorithm of temperature correction of refractometric data.
Keywords: refractometric system, botulinum toxin, refractive index, aesthetic cosmetology, temperature coefficient, concentration

References:
  1. Tordjman M. J. Med. Esth. Chir. Dermatol., 2003, vol. 118, pp. 111–118.
  2. Baumann L. Cosmetic Dermatology: principles and practice, Medpress-inform, 2013, pp. 288–325.
  3. Kurlov V.V., Gromov O.V., Tayurskaya I.S., Maiorov E.E., Arefiev A.V., Guliyev R.B. Instruments and Systems: Monitoring, Control, and Diagnostics, 2021, no. 2, pp. 1–12. DOI: 10.25791/pribor.2.2021.1237(in Russ.)
  4. Gromov V.O., Mayorov E.E., Tayurskaya I.S., Mashek A.Ch., Tsygankova G.A., Udakhina S.V. Scientific Review. Technical science, 2021, no. 3, pp. 21–26. (in Russ.)
  5. Maiorov E.E., Turovskaya M.S., Khokhlova M.V., Shalamay L.I., Konstantinova A.A., Dagaev A.V., Guliyev R.B., Tayurskaya I.S. News of the Tula State University. Technical sciences, 2020, no. 2, pp. 129–137. (in Russ.)
  6. Guliyev R.B., Koskovich V.B., Pushkina V.P., Khokhlova M.V., Konstantinova A.A. The Scientific Heritage, 2019, no. 40(1), pp. 35–40.
  7. Kurlov V.V., Kotskovich V.B., Majorov E.E., Pushkina V.P., Tayurskaya I.S. News of the Tula State University. Technical sciences, 2020, no. 8, pp. 179–189. (in Russ.)
  8. Maiorov Е.Е., Kurlov V.V., Gromov O.V., Guliyev R.B., Dagaev A.V., Tayurskaya I.S. News of the Tula State University. Technical sciences, 2021, no. 6, pp. 170–175, DOI: 10.24412/2071-6168-2021-6-170-175. (in Russ.)
  9. Antoniou C., Kosmadaki M.G., Stratiges A.J., Katsambas A.D. Am. J. Clin. Dermatol., 2010, vol. 11, pp. 95–102.
  10. Fournier N. Kerscher M., Ruiz-Avila J. Dermatol. Surg., 2013, no. 3(39), pp. 510–525.
  11. Lin K.H. Chen S.P., Fuh J.L. J. Chin. Med. Assoc., 2014, no. 1(77), pp. 10–15.
  12. Mikhalchevsky Yu.Yu., Kostin G.A., Maiorov E.E., Arefiev A.V., Guliyev R.B., Dagaev A.V. Instruments and Systems: Monitoring, Control, and Diagnostics, 2021, no. 10, pp. 1–7, DOI: 10.25791/pribor.10.2021.1294. (in Russ.)
  13. Mikhalchevsky Yu.Yu., Kostin G.A., Maiorov E.E., Kurlov V.V., Guliyev R.B., Dagaev A.V. News of the Tula State University. Technical sciences, 2021, no. 10, pp. 170–175, DOI: 10.24412/2071-6168-2021-6-170-175. (in Russ.)
  14. Mikhalchevsky Yu.Yu., Kostin G.A., Maiorov E.E., Arefiev A.V., Khokhlova M.V., Udakhina S.V. Nauchnoe Priborostroenie (Scientific Instrumentation, 2021, no. 4(31), pp. 88–101. (in Russ.)